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Filtered Search Results
Medchemexpress LLC Recombinant mouse interleukin-31 (IL-31) | >85.0% | 50 UG
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Recombinant mouse interleukin-31 (IL-31) produced in HEK293 cells with a C-terminal His tag, supplied as a 0.22 μm filtered solution in PBS (pH 7.4). The protein is designed for biochemical and cell-based assays, including receptor binding and signaling studies; manufacturer provides activity, purity, and storage data.
- Expressed in HEK293 mammalian cells.
- C-terminal His tag for detection and purification.
- Supplied in PBS (pH 7.4), 0.22 μm filtered.
- >85.0% purity by reducing SDS-PAGE.
- Approximate molecular weight 17.1 kDa (reducing SDS-PAGE).
- Bioactivity: ED50 ≈ 2.916 μg/mL in receptor-binding ELISA.
- Store long-term at -80°C; avoid repeated freeze-thaw.
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eMolecules 955887-09-9 | tert-Butyl 4-bromo-2,6-difluorobenzoate | MFCD08703422 | 1g
Ambeed | tert-Butyl 4-bromo-2,6-difluorobenzoate | 1g | 525233426 | A684468 | 955887-09-9 | MFCD08703422 | 293.108 | C11H11BrF2O2
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Medchemexpress LLC Quin C1 | 786706-21-6 | 98.5% | 445.51 | 500 UG
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Quin C1 is a highly specific and potent agonist for formyl peptide receptor 2 (FPR2/ALX). It significantly reduces neutrophil and lymphocyte counts in BALF, diminishes expression of TNF-α, IL-1β, KC, and TGF-β1, and decreases collagen deposition in lung tissue.
- Highly specific and potent agonist for formyl peptide receptor 2 (FPR2/ALX)
- Significantly reduces neutrophil and lymphocyte counts in BALF
- Diminishes expression of TNF-α, IL-1β, KC, and TGF-β1
- Decreases collagen deposition in lung tissue
- Potential for research into lung injury
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Apexbio Technology LLC GSK1838705A 1116235-97-2 200mg
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GSK1838705A (CAS 1116235-97-2) is a small molecule inhibitor targeting the kinase activity of insulin-like growth factor-1 receptor (IGF-1R) insulin receptor and anaplastic lymphoma kinase (ALK) It exhibits potent inhibition with IC50 values of 2 0 nM for IGF-1R 1 6 nM for insulin receptor and 0 5 nM for ALK In preclinical research GSK1838705A suppresses proliferation of hematologic malignancy-derived tumor cells including multiple myeloma and Ewing sarcoma lines and inhibits tumor xenograft growth in vivo Additionally despite targeting the insulin receptor it minimally affects glucose homeostasis at effective doses Due to its multi-target kinase inhibitory profile GSK1838705A serves as a promising tool for cancer biology research
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Apexbio Technology LLC SM-164 957135-43-2 200mg
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SM-164 (CAS 957135-43-2) is a bivalent small molecule mimetic of the endogenous inhibitor Smac designed to antagonize cellular inhibitor of apoptosis proteins (cIAP-1 cIAP-2) and X-linked inhibitor of apoptosis protein (XIAP) By binding specifically to the BIR2 and BIR3 domains of cIAP-1 and XIAP as well as the BIR3 domain of cIAP-2 (Ki of 0 31 nM 0 56 nM and 1 1 nM respectively) SM-164 promotes degradation of cIAP-1 and inhibition of XIAP In tumor cells this leads to caspase activation and TNF -dependent apoptosis SM-164 is utilized in cancer research to investigate apoptosis regulation and anticancer therapy strategies
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Medchemexpress LLC Romaciclib monohydrochloride | 2443816-41-7 | 99.29% | 450.60 | 10 MG
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Romaciclib monohydrochloride (SEL120-34A monohydrochloride) is an ATP-competitive and selective inhibitor of Cyclin-Dependent Kinase 8 (CDK8). It demonstrates potent inhibitory activity against the kinase complexes of CDK8/CycC and CDK19/CycC, with IC50 values of 4.4 nM and 10.4 nM, respectively, and a Kd of 3 nM for CDK8. While it weakly inhibits CDK9, it shows no significant activity against other CDKs such as CDK1, 2, 4, 6, 5, and 7. The compound effectively inhibits the phosphorylation of STAT1 S727 and STAT5 S726 and has demonstrated anti-tumor activity.
- Selective inhibition of specific cyclin-dependent kinases.
- ATP-competitive mechanism of action.
- Impacts key signaling pathways by inhibiting STAT1 S727 and STAT5 S726 phosphorylation.
- Demonstrated efficacy in anti-tumor applications.
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Medchemexpress LLC 5-Hydroxyquinoline | 578-67-6 | 99.5% | 145.16 | 100 G
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5-Hydroxyquinoline is an organic compound commonly used in certain chemical reactions and biological research. It can be used in the manufacture of dyes, cellulase, oxidants and passivators, and is widely applied in the pigment, paint, and rubber industries. Additionally, it serves as a precursor, intermediate, and metal ion complexing agent for certain drugs.
- Appearance: Solid
- Shipping: Room temperature in continental US; may vary elsewhere
- Storage: Powder at -20°C for 3 years, 4°C for 2 years; In solvent at -80°C for 6 months, -20°C for 1 month
- Solubility: In DMSO at 50 mg/mL (344.45 mM)
- Usage: For research use only
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Medchemexpress LLC m-PEG9-Amine | 211859-73-3 | >97.0% | 5 G
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m-PEG9-Amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs, and also functions as a cleavable ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs). It facilitates the construction of compounds that either selectively degrade target proteins via the ubiquitin-proteasome system or enable targeted delivery of cytotoxic drugs.
- Functions as a PEG-based PROTAC linker
- Suitable for the synthesis of PROTACs
- Acts as a cleavable ADC linker
- Used in the synthesis of antibody-drug conjugates (ADCs)
- Supports targeted protein degradation via the ubiquitin-proteasome system
- Enables targeted delivery of cytotoxic drugs
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![Medchemexpress LLC Trimethyl[2,3-(dioleyloxy)propyl]ammonium chloride | 104162-48-3 | MFCD00145456 | 98.0% | 670.57 g/mol | C42H84ClNO2 | 50 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000282662.png-250.jpg)
Medchemexpress LLC Trimethyl[2,3-(dioleyloxy)propyl]ammonium chloride | 104162-48-3 | MFCD00145456 | 98.0% | 670.57 g/mol | C42H84ClNO2 | 50 MG
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Trimethyl[2,3-(dioleyloxy)propyl]ammonium chloride is a quaternary ammonium, lipid-like reagent used in life-science research. It acts as an amphiphilic cationic lipid for formulation and membrane studies, and can be used as a surfactant or helper lipid in experimental delivery systems. The material is supplied with product documentation and handling information and is intended for research use only.
- Quaternary ammonium headgroup provides cationic charge.
- Two dioleoyl chains confer lipid-like amphiphilicity.
- Amphiphilic character supports bilayer and vesicle formulation.
- Soluble in common organic solvents for formulation workflows.
- Provided with documentation and safety data for lab use.
- Store sealed and away from moisture; refrigerate for prolonged stability.
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000760428 2 5 -DIMETHOXY-1 1 1G
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Medchemexpress LLC 2-Octyl-4(1H)-quinolone | 80554-60-5 | ≥98.0% | 257.37 | 100 MG
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2-Octyl-4(1H)-quinolone, also known as Compound 14, is a quinolinone alkaloid that can be isolated from the plant Ruta graveolens. It is intended for research use only.
- It is a natural product derived from Ruta graveolens.
- It exhibits antiproliferative activity against human A2780 cells.
- The IC50 value for its antiproliferative activity against A2780 cells is 12 μM after 2 days by Alamar blue assay.
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Medchemexpress LLC Amino-PEG5-amine | 72236-26-1 | 97.0% | 100 MG
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Amino-PEG5-amine is a PEG-based PROTAC linker with 5 units. It is designed for use in the synthesis of PROTACs and is intended for research purposes only.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- For research use only
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000772784 1 1 2-TRIMETHYL-3-4 5G
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Medchemexpress LLC Etonogestrel | 54048-10-1 | 99.9% | 200 MG
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Etonogestrel is an active metabolite of Desogestrel, functioning as a third-generation progesterone analogue used in various oral contraceptive preparations. It also serves as a click chemistry reagent, featuring an Alkyne group that enables participation in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Etonogestrel is known to decrease PHOX2B expression by binding to the progesterone nuclear receptor PR-B.
- Third-generation progesterone analogue
- Included in oral contraceptive preparations
- Click chemistry reagent with an Alkyne group
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Decreases PHOX2B expression by binding to the progesterone nuclear receptor PR-B
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![eMolecules 957486-82-7 | Azido-PEG6-amine | ChemScene | MFCD03453240 | 350.416 | C14H30N4O6 | 97.000 | NCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-] | 250mg | 672544878](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000126202.jpg-250.jpg)
eMolecules 957486-82-7 | Azido-PEG6-amine | ChemScene | MFCD03453240 | 350.416 | C14H30N4O6 | 97.000 | NCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-] | 250mg | 672544878
Azido-PEG6-amine | ChemScene | 957486-82-7 | MFCD03453240 | 350.416 | C14H30N4O6 | 97.000 | NCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-] | 250mg | 672544878
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